The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.

Lorthiois, Edwige; Breitenstein, Werner; Cumin, Frederic; Ehrhardt, Claus; Francotte, Eric; Jacoby, Edgar; Ostermann, Nils; Sellner, Holger; Kosaka, Takatoshi; Webb, Randy L; Rigel, Dean F; Hassiepen, Ulrich; Richert, Paul; Wagner, Trixie; Maibaum, Jürgen

Lorthiois, Edwige; Breitenstein, Werner; Cumin, Frederic; Ehrhardt, Claus; Francotte, Eric; Jacoby, Edgar; Ostermann, Nils; Sellner, Holger; Kosaka, Takatoshi; Webb, Randy L; Rigel, Dean F; Hassiepen, Ulrich; Richert, Paul; Wagner, Trixie; Maibaum, Jürgen.

Affiliation

Lorthiois E; Novartis Pharma AG, Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland. edwige.lorthiois@novartis.com

J Med Chem ; 56(6): 2207-17, 2013 Mar 28.

Article in En | MEDLINE | ID: mdl-23425156

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Pyrrolidines / Models, Molecular / Renin / Drug Discovery Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Suiza

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