Effect of ondansetron in preventing postoperative nausea and vomiting under different conditions of general anesthesia: a preliminary, randomized, controlled study.
Ups J Med Sci
; 118(2): 87-90, 2013 May.
Article
in En
| MEDLINE
| ID: mdl-23441598
ABSTRACT
METHODS:
Two hundred and forty patients were randomly allocated into six groups Group I, anesthesia was maintained with sevoflurane; Group II, anesthesia was maintained with sevoflurane and 8 mg of ondansetron; Group III, anesthesia was maintained with propofol; Group IV, anesthesia was maintained with propofol and 8 mg of ondansetron; Group V, anesthesia was maintained with sevoflurane and propofol; Group VI, anesthesia was maintained with sevoflurane combined with propofol and 8 mg of ondansetron.RESULTS:
We found that the incidence of vomiting was lower in group II (17.5%), group IV (7.5%), and group VI (10%) compared with group I (55%), group III (27.5%), and group V (30%), respectively (P < 0.05). The incidence of vomiting was also lower in group III (27.5%) and group V (30%) when compared with group I (55%) (P < 0.05). The incidence of nausea was 55% in group I, 42.5% in group II, 30% in group III, 27.5% in group IV, 30% in group V, and 30% in group VI. Groups III and V had a lower incidence of nausea than group I (P < 0.05).CONCLUSIONS:
We conclude that compared with sevoflurane anesthesia alone, anesthesia with either propofol alone or propofol combined with sevoflurane resulted in a reduced incidence of vomiting and nausea during the first 24 h after surgery. Administration of ondansetron effectively reduced the incidence of vomiting but not that of nausea for all three types of general anesthesia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Serotonin Antagonists
/
Ondansetron
/
Postoperative Nausea and Vomiting
/
Anesthesia, General
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
Ups J Med Sci
Year:
2013
Document type:
Article
Affiliation country:
China