[Development of siRNA delivery strategy by active control of tumor microenvironment].
Yakugaku Zasshi
; 133(3): 379-86, 2013.
Article
in Ja
| MEDLINE
| ID: mdl-23449418
Efficient systemic siRNA delivery to cells in the target tissue is a current critical challenge in the drug delivery field. Several studies have demonstrated that nanoparticles such as polyethylene glycol (PEG)-coated siRNA-lipoplexes may enhance the systemic delivery of siRNA to tumor. However, the disordered tumor microenvironment still poses a potential impediment with respect to the efficient delivery of PEG-coated siRNA-lipoplexes. We recently showed that metronomic S-1 dosing (daily oral administration) enhanced the accumulation of PEG-coated liposome containing anticancer drug in solid tumor tissue and thereby increased therapeutic efficacy in tumor-bearing mouse model. To extend this work, we tried to investigate the effect of metronomic S-1 dosing on the intratumoral accumulation of PEG-coated siRNA-lipoplex and, thereby, their therapeutic efficacy in solid tumor-bearing mouse model. Results showed that metronomic S-1 dosing improved systemic delivery of intravenously injected PEG-coated siRNA-lipoplexes into solid tumor tissue. In addition, the combined therapy of S-1 and PEG-coated siRNA-lipoplexes showed potent tumor growth suppressive effect. Our proposed strategy may pose a promising therapeutic one to conquer cancer progression with siRNA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Delivery Systems
/
RNA, Small Interfering
/
Tumor Microenvironment
Limits:
Animals
Language:
Ja
Journal:
Yakugaku Zasshi
Year:
2013
Document type:
Article
Affiliation country:
Japón
Country of publication:
Japón