Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
Neuroscience
; 243: 46-53, 2013 Jul 23.
Article
in En
| MEDLINE
| ID: mdl-23558088
ABSTRACT
L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercise (running wheel) during 2 weeks. Exercise drastically prevented the development of LID, and its associated aberrant striatal signaling, namely the hyperphosphorylation of dopamine and cAMP-regulated phosphoprotein 32 kDa protein and c-Fos expression. Our results indicate that exercise can partially prevent the development of LID through the normalization of striatopallidal dopaminergic signaling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Levodopa
/
Parkinsonian Disorders
/
Dyskinesia, Drug-Induced
/
Antiparkinson Agents
Limits:
Animals
Language:
En
Journal:
Neuroscience
Year:
2013
Document type:
Article
Affiliation country:
Brasil