Genetic variants of the genes encoding zinc finger protein 313 and interleukin-13 confer a risk for psoriasis in a Chinese Uygur population.
Clin Exp Dermatol
; 38(7): 768-74, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23617596
ABSTRACT
BACKGROUND:
Recent work using genomewide association studies (GWAS) in Chinese Han and white populations have discovered several novel psoriasis susceptibility genes.AIM:
To examine whether the risk loci for psoriasis identified in previous GWAS in a white population are also associated with psoriasis in a Chinese Uygur population in Xinjiang.METHODS:
Genotyping analysis of eight single-nucleotide polymorphisms (SNPs) associated with psoriasis was performed for 539 patients with psoriasis and 749 controls, all of Chinese Uygur descent, using a commercial assay.RESULTS:
Two SNPs had an association with psoriasis in this Chinese Uygur population SNP rs495337 in the gene encoding for zinc finger protein 313 (P < 0.001; OR = 0.80) and SNP rs20541 of the gene encoding for interleukin-13 (P < 0.001; OR = 0.82). In subgroup analyses, the two SNPs were significantly associated (P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients. Interestingly, using multifactor dimensionality reduction, a significant two-locus interaction was seen between rs495337 and rs20541, with a crossvalidation consistency of 4/5 and average balanced prediction (accuracy 55.5%, P < 0.001).CONCLUSIONS:
ZNF313 and IL-13 are associated with risk for psoriasis in a Chinese Uygur population, and there is an effect of interaction between the two genes on this risk.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psoriasis
/
Carrier Proteins
/
Interleukin-13
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Clin Exp Dermatol
Year:
2013
Document type:
Article