Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit.
J Mol Biol
; 425(20): 3907-10, 2013 Oct 23.
Article
in En
| MEDLINE
| ID: mdl-23702293
ABSTRACT
Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as potential antiprotozoal and antitumor drugs. Here, we report a 3.1-Å crystal structure of de-6-MSA-pactamycin bound to its target site on the Thermus thermophilus 30S ribosomal subunit. Although de-6-MSA-pactamycin lacks the MSA moiety, it shares the same binding site as pactamycin and induces a displacement of nucleic acid template bound at the E-site of the 30S. The structure highlights unique interactions between this pactamycin analog and the ribosome, which paves the way for therapeutic development of related compounds.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pactamycin
/
Ribosome Subunits, Small, Bacterial
Language:
En
Journal:
J Mol Biol
Year:
2013
Document type:
Article
Affiliation country:
Reino Unido