Anti-proliferative actions of N'-desmethylsorafenib in human breast cancer cells.

Cui, Pei H; Rawling, Tristan; Gillani, Tina B; Bourget, Kirsi; Wang, Xiao-Suo; Zhou, Fanfan; Murray, Michael

Cui, Pei H; Rawling, Tristan; Gillani, Tina B; Bourget, Kirsi; Wang, Xiao-Suo; Zhou, Fanfan; Murray, Michael.

Affiliation

Cui PH; Pharmacogenomics and Drug Development Group, Discipline of Pharmacology, University of Sydney, NSW 2006, Australia.

Biochem Pharmacol ; 86(3): 419-27, 2013 Aug 01.

Article in En | MEDLINE | ID: mdl-23732299

Subject(s)
Key words

Breast cancer cells; CYP; DMEM; Dulbecco's Modified Eagle Medium; ERK; ERK kinase; LCMSMS; MEK; MEK/ERK signaling; Mcl-1; N'-Desmethylsorafenib; PBS; Pharmacokinetic drug interactions; RIPA; Sorafenib; VEGF; cytochrome P450; extracellular signal-regulated kinase; liquid chromatographytandem mass spectrometry; myeloid cell leukemia sequence-1; phosphate-buffered saline; radioimmunoprecipitation; vascular endothelial growth factor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Breast Neoplasms / Niacinamide / Cell Proliferation / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Biochem Pharmacol Year: 2013 Document type: Article Affiliation country: Australia Country of publication: Reino Unido

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