A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.
Chembiochem
; 14(10): 1198-203, 2013 Jul 08.
Article
in En
| MEDLINE
| ID: mdl-23744829
ABSTRACT
Natural amino donation A PLP-dependent aminotransferase PctV, encoded in the pactamycin biosynthetic gene cluster, was found to catalyze the formation of 3-aminobenzoate from 3-dehydroshikimate with L-glutamate as the amino donor. The PctV reaction comprises a transamination and two dehydration reactions. This is the first report of a simple 3-ABA synthase in nature.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pactamycin
/
Shikimic Acid
/
Meta-Aminobenzoates
Language:
En
Journal:
Chembiochem
Journal subject:
BIOQUIMICA
Year:
2013
Document type:
Article
Affiliation country:
Japón