Computational analysis of four human adenovirus type 4 genomes reveals molecular evolution through two interspecies recombination events.
Virology
; 443(2): 197-207, 2013 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-23763770
ABSTRACT
Computational analysis of human adenovirus type 4 (HAdV-E4), a pathogen that is the only HAdV member of species E, provides insights into its zoonotic origin and molecular adaptation. Its genome encodes a domain of the major capsid protein, hexon, from HAdV-B16 recombined into the genome chassis of a simian adenovirus. Genomes of two recent field strains provide a clue to its adaptation to the new host recombination of a NF-I binding site motif, which is required for efficient viral replication, from another HAdV genome. This motif is absent in the chimpanzee adenoviruses and the HAdV-E4 prototype, but is conserved amongst other HAdVs. This is the first report of an interspecies recombination event for HAdVs, and the first documentation of a lateral partial gene transfer from a chimpanzee AdV. The potential for such recombination events are important when considering chimpanzee adenoviruses as candidate gene delivery vectors for human patients.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenoviruses, Human
/
Adenoviruses, Simian
/
Genome, Viral
/
Evolution, Molecular
/
Computational Biology
/
Gene Transfer, Horizontal
Limits:
Animals
/
Humans
Language:
En
Journal:
Virology
Year:
2013
Document type:
Article
Affiliation country:
Estados Unidos