Relapsing polychondritis complicated by giant cell myocarditis and myositis.
Intern Med
; 52(12): 1397-402, 2013.
Article
in En
| MEDLINE
| ID: mdl-23774555
ABSTRACT
An 83-year-old man presented with a three-week history of dyspnea. The clinical features suggested a diagnosis of relapsing polychondritis (RP); however, the patient died of heart failure. An autopsy revealed active chondritis of the tracheal and bronchial cartilage. Furthermore, giant cell myocarditis (GCM) and myositis were detected. To the best of our knowledge, this represents the first report of RP complicated by GCM and myositis. In patients with RP, GCM and myositis, CD163-positive macrophages and T-cells are most common, and the T-cell subset exhibits CD8 predominance. Common mechanisms of tissue damage caused by cytotoxic T-cells are likely to contribute to RP, GCM and myositis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polychondritis, Relapsing
/
Myocarditis
/
Myositis
Type of study:
Diagnostic_studies
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
En
Journal:
Intern Med
Journal subject:
MEDICINA INTERNA
Year:
2013
Document type:
Article
Affiliation country:
Japón