Fibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer.
Head Neck
; 36(9): 1253-7, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-23913758
ABSTRACT
BACKGROUND:
Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer.METHODS:
One hundred twelve primary tumors (including squamous cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number status. Human papillomavirus (HPV) status was assessed by p16 immunohistochemical as a surrogate marker.RESULTS:
FGFR1 amplification was found in subsets of sinonasal SCCs (20%), carcinomas associated with an inverted papilloma (33%), and SNUCs (5%). In all cases, metastatic tumor samples shared the same FGFR1 amplification status as the corresponding primary tumor tissue. None of the FGFR1-amplified tumors expressed p16.CONCLUSION:
FGFR1 amplification represents a potential molecular target in a subset of patients with sinonasal cancer. © 2014 Wiley Periodicals, Inc. Head Neck 36 1253-1257, 2014.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paranasal Sinus Neoplasms
/
Carcinoma, Squamous Cell
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Adenocarcinoma
/
Papilloma, Inverted
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Esthesioneuroblastoma, Olfactory
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Receptor, Fibroblast Growth Factor, Type 1
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2014
Document type:
Article
Affiliation country:
Alemania