Towards an integrated experimental-theoretical approach for assessing the mechanistic basis of hair and feather morphogenesis.
Interface Focus
; 2(4): 433-50, 2012 Aug 06.
Article
in En
| MEDLINE
| ID: mdl-23919127
ABSTRACT
In his seminal 1952 paper, 'The Chemical Basis of Morphogenesis', Alan Turing lays down a milestone in the application of theoretical approaches to understand complex biological processes. His deceptively simple demonstration that a system of reacting and diffusing chemicals could, under certain conditions, generate spatial patterning out of homogeneity provided an elegant solution to the problem of how one of nature's most intricate events occurs the emergence of structure and form in the developing embryo. The molecular revolution that has taken place during the six decades following this landmark publication has now placed this generation of theoreticians and biologists in an excellent position to rigorously test the theory and, encouragingly, a number of systems have emerged that appear to conform to some of Turing's fundamental ideas. In this paper, we describe the history and more recent integration between experiment and theory in one of the key models for understanding pattern formation the emergence of feathers and hair in the skins of birds and mammals.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Interface Focus
Year:
2012
Document type:
Article
Affiliation country:
Reino Unido