Elevated Aß42 in aged, non-demented individuals with cerebral atherosclerosis.
Curr Alzheimer Res
; 10(8): 785-9, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23919773
ABSTRACT
The ß-secretase, BACE1, generates ß-amyloid (Aß), a major hallmark of Alzheimer's disease (AD) pathology. The elevation of BACE1 levels in brains of AD patients may play a role in initiating or propagating disease. BACE1 levels are increased under low energy or low oxygen conditions, which may occur in individuals with impaired circulation in the brain. We compared levels of BACE1 in the brains of aged, non-demented individuals with high or low levels of atherosclerosis in the circle of Willis, and found that while there is no change in BACE1, Aß42 levels are elevated in the high atherosclerosis group.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Intracranial Arteriosclerosis
/
Amyloid beta-Peptides
/
Frontal Lobe
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Curr Alzheimer Res
Journal subject:
NEUROLOGIA
Year:
2013
Document type:
Article