Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.
J Alzheimers Dis
; 38(1): 171-84, 2014.
Article
in En
| MEDLINE
| ID: mdl-23948934
ABSTRACT
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidines
/
Benzimidazoles
/
Brain
/
Tau Proteins
/
Fluorodeoxyglucose F18
/
Alzheimer Disease
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Estados Unidos