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Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
Betschart, Claudia; Hintermann, Samuel; Behnke, Dirk; Cotesta, Simona; Fendt, Markus; Gee, Christine E; Jacobson, Laura H; Laue, Grit; Ofner, Silvio; Chaudhari, Vinod; Badiger, Sangamesh; Pandit, Chetan; Wagner, Juergen; Hoyer, Daniel.
Affiliation
  • Betschart C; Global Discovery Chemistry, ‡Neuroscience, and §Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.
J Med Chem ; 56(19): 7590-607, 2013 Oct 10.
Article in En | MEDLINE | ID: mdl-23964859
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep / Spiro Compounds / Orexin Receptor Antagonists / Sleep Initiation and Maintenance Disorders Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Suiza
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sleep / Spiro Compounds / Orexin Receptor Antagonists / Sleep Initiation and Maintenance Disorders Type of study: Diagnostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: Suiza