Association between dietary folate intake and serum insulin-like growth factor-1 levels in healthy old women.
Growth Horm IGF Res
; 23(6): 267-71, 2013 Dec.
Article
in En
| MEDLINE
| ID: mdl-24090688
ABSTRACT
OBJECTIVE:
High serum levels of insulin-like growth factor-1 (IGF-1) seem to coincide with higher rates of some types of cancer and the risk of all-cause mortality in old people. Eating vegetables seems to reduce IGF-1 levels because they are rich in micronutrients such as vitamins. This study investigates the possible association between vitamin intake and IGF-1 levels in a representative group of healthy elderly women with Mediterranean dietary habits.DESIGN:
This cross-sectional study included 124 healthy women with a mean age of 71.3 ± 4.2 years and a mean body mass index (BMI) of 27.37 ± 3.48 kg/m(2) attending a mild fitness program twice a week at public gyms in Padova. The main parameters considered were IGF-1 (measured by chemiluminescence) and diet, assessed on the basis of a 3-day record and a questionnaire on the frequency with which they usually ate certain foods.RESULTS:
The mean IGF-1 level for the sample as a whole was 136.2 ± 38.9 µg/l, and was significantly lower in women with a higher folate intake (p = 0.04). On simple linear analysis, the vitamins found associated with serum IGF-1 levels were folates (r -0.25; p = 0.003); vitamin E (r -0.21; p = 0.01); vitamin D (r -0.17; p = 0.03); and riboflavin (r -0.16; p=0.03). After removing the effect of calorie, protein, carbohydrate and fat intake, and other known potential confounders (age, BMI, alcohol intake), only folate intake correlated with IGF-1 levels (r = -0.17; p = 0.04).CONCLUSION:
A folate-rich diet could have the effect of lowering circulating IGF-1 levels in elderly women.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin-Like Growth Factor I
/
Biomarkers
/
Diet, Mediterranean
/
Eating
/
Folic Acid
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
Language:
En
Journal:
Growth Horm IGF Res
Journal subject:
ENDOCRINOLOGIA
Year:
2013
Document type:
Article
Affiliation country:
Italia