Tolerance and chimerism and allogeneic bone marrow/stem cell transplantation in liver transplantation.
World J Gastroenterol
; 19(36): 5981-7, 2013 Sep 28.
Article
in En
| MEDLINE
| ID: mdl-24106398
ABSTRACT
The liver has particular tolerogenic properties that allow its spontaneous acceptance in some animal species. Liver structure is considered to favor a tolerogenic environment. The peripheral tolerance mechanisms also play a role in spontaneous tolerance to liver graft. In a clinical setting, the main challenge nowadays facing liver transplantation is minimization of immunosuppression with the goal of donor-specific tolerance. Mechanisms involved in tolerance to transplanted organs are complex and partly unknown. A significant mechanism in tolerance induction is chimerism. Chimerism can be induced through transplantation of allogeneic donor bone marrow/stem cells under appropriate host conditioning. This review focuses on the tolerance mechanisms in liver transplantation and highlights the role of chimerism and allogeneic bone marrow/stem cell transplantation in tolerance development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stem Cells
/
Bone Marrow Cells
/
Bone Marrow Transplantation
/
Liver Transplantation
/
Transplantation Chimera
/
Transplantation Tolerance
/
Stem Cell Transplantation
/
Liver
Limits:
Animals
/
Humans
Language:
En
Journal:
World J Gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2013
Document type:
Article
Affiliation country:
China