Fat emulsion given to very low-birthweight infants increases urinary L-FABP.
Pediatr Int
; 56(2): 207-10, 2014 Apr.
Article
in En
| MEDLINE
| ID: mdl-24106822
ABSTRACT
BACKGROUND:
In premature infants, many factors influence the function of renal tubules, such as asphyxia, respiratory disorders, use of high-concentration oxygen, hypotension, and drug treatment. When tubular ischemia and oxidative stress develop due to renal microcirculatory pathology, urinary L-type fatty acid-binding protein (L-FABP) level increases.METHODS:
Urinary L-FABP level was measured over time in very low-birthweight infants (VLBWI), and the effect of fat emulsion on L-FABP level was investigated. Thirty-one VLBWI were divided into two groups with regard to treatment with fat emulsion the lipid group (n = 20) and the control group (n = 11). Urinary L-FABP was measured before (0-3 days of age), during (7-14 days of age), and after fat emulsion treatment (21-28 days of age) in the two groups.RESULTS:
Median urinary L-FABP level before treatment was 459 ng/mgCr (range, 22.7-5100 ng/mgCr; mean, 1067 ± 1570 ng/mgCr) and 797 ng/mgCr (range, 69-3900 ng/mgCr; mean, 1066 ± 1188 ng/mgCr) in the lipid and control groups, respectively, showing no significant difference. Median urinary L-FABP level was 624 ng/mgCr (range, 50-2050 ng/mgCr; mean ± SD, 799 ± 655 ng/mgCr) and 273 ng/mgCr (range, 31-987 ng/mgCr; mean ± SD, 359 ± 323 ng/mgCr) at 7-14 days of age, respectively, showing that the level was significantly higher in the lipid group. At 21-28 days of age, the median level was 462 ng/mgCr (range, 49-1867 ng/mgCr; mean ± SD, 557 ± 534 ng/mgCr) and 130 ng/mgCr (range, 20-993 ng/mgCr; mean ± SD, 290 ± 329 ng/mgCr), respectively, showing that L-FABP level tended to be higher in the lipid group.CONCLUSIONS:
Fat emulsion treatment induced a significant increase in urinary L-FABP level, suggesting that fat emulsion affected the proximal tubule in VLBWI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infant, Very Low Birth Weight
/
Fatty Acid-Binding Proteins
/
Fat Emulsions, Intravenous
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Pediatr Int
Journal subject:
PEDIATRIA
Year:
2014
Document type:
Article
Affiliation country:
Japón
Publication country:
AU
/
AUSTRALIA
/
AUSTRÁLIA