Treatment of AVN using the induction chamber technique and a biological-based approach: indications and clinical results.
Injury
; 45(2): 369-73, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-24119830
ABSTRACT
OBJECTIVE:
To determine the efficacy of core decompression (CD) technique combined with recombinant morphogenetic proteins, autologous mesenchymal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head. PATIENTS ANDMETHODS:
A total of 38 patients (40 hips) with early stage osteonecrosis of the femoral head were studied over a 4-year period.RESULTS:
CD technique combined with recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute was associated with a significant reduction in both pain and joint symptoms and reduced the incidence of fractural stages. At 36 months, 33 patients achieved clinical and radiographic healing.CONCLUSION:
This long-term follow-up study confirmed that CD technique combined with recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute may be an effective treatment for patients with early stage osteonecrosis of the femoral head.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteonecrosis
/
Bone Marrow Transplantation
/
Decompression, Surgical
/
Mesenchymal Stem Cell Transplantation
/
Femur Head Necrosis
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Injury
Year:
2014
Document type:
Article