Postoperative 5-FU based radiochemotherapy in rectal cancer: retrospective long term results and prognostic factors of a pooled analysis on 1,338 patients.
Anticancer Res
; 33(10): 4557-66, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-24123031
ABSTRACT
AIM:
To evaluate survival outcomes of patients in pStage II-III rectal cancer treated with adjuvant 5-fluorouracil-based radiochemotherapy and to retrospectively analyze the impact of prognostic variables on local control, metastasis-free survival and cause-specific survival. PATIENTS ANDMETHODS:
A total of 1,338 patients, treated between 1985-2005 for locally advanced rectal cancer, who underwent surgery and postoperative 5-fluorouracil-based chemoradiation, were selected.RESULTS:
The actuarial 5- and 10-year outcomes were local control 87.0%-84.1%, disease-free survival 61.6%-52.1%, metastasis-free survival 72.0%-67.2%, cause-specific survival 70.4%-57.5%, and overall survival 63.8%-53.4%. Better outcomes were observed in patients with IIA, IIIA stage. Multivariate analyses showed that variables significantly affecting metastasis-free survival were pT4 and pN2, while for cancer-specific survival those variables were age >65 years, pT4, pN1, pN2, distal tumors and number of lymph nodes removed ≤ 12.CONCLUSION:
This study confirmed that among stage II-III rectal cancer patients there are subgroups of patients with different clinical outcomes.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rectal Neoplasms
/
Fluorouracil
/
Antimetabolites, Antineoplastic
Type of study:
Observational_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Anticancer Res
Year:
2013
Document type:
Article
Affiliation country:
Italia