Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.

Elcombe, Clifford R; Peffer, Richard C; Wolf, Douglas C; Bailey, Jason; Bars, Remi; Bell, David; Cattley, Russell C; Ferguson, Stephen S; Geter, David; Goetz, Amber; Goodman, Jay I; Hester, Susan; Jacobs, Abigail; Omiecinski, Curtis J; Schoeny, Rita; Xie, Wen; Lake, Brian G

Elcombe, Clifford R; Peffer, Richard C; Wolf, Douglas C; Bailey, Jason; Bars, Remi; Bell, David; Cattley, Russell C; Ferguson, Stephen S; Geter, David; Goetz, Amber; Goodman, Jay I; Hester, Susan; Jacobs, Abigail; Omiecinski, Curtis J; Schoeny, Rita; Xie, Wen; Lake, Brian G.

Affiliation

Elcombe CR; CXR Biosciences Ltd , Dundee , UK .

Crit Rev Toxicol ; 44(1): 64-82, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24180433

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenobarbital / Receptors, Cytoplasmic and Nuclear / Liver / Liver Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Crit Rev Toxicol Journal subject: TOXICOLOGIA Year: 2014 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido

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