Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus.
Bioorg Med Chem Lett
; 24(1): 367-70, 2014 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-24269165
ABSTRACT
This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25µg/mL as compared to that of methicillin (3.125µg/mL) against Staphylococcus aureus.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Staphylococcus aureus
/
Oxyquinoline
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2014
Document type:
Article