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Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic.
Lee, Youn-Bok; Chen, Han-Jou; Peres, João N; Gomez-Deza, Jorge; Attig, Jan; Stalekar, Maja; Troakes, Claire; Nishimura, Agnes L; Scotter, Emma L; Vance, Caroline; Adachi, Yoshitsugu; Sardone, Valentina; Miller, Jack W; Smith, Bradley N; Gallo, Jean-Marc; Ule, Jernej; Hirth, Frank; Rogelj, Boris; Houart, Corinne; Shaw, Christopher E.
Affiliation
  • Lee YB; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Chen HJ; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Peres JN; MRC Centre for Developmental Neurobiology, London SE1 1UL, UK.
  • Gomez-Deza J; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Attig J; Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Stalekar M; Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
  • Troakes C; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Nishimura AL; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Scotter EL; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Vance C; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Adachi Y; Department of Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Sardone V; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK; Department of Public Health, Neuroscience, Experimental, and Forensic Medicine, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.
  • Miller JW; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Smith BN; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Gallo JM; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Ule J; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
  • Hirth F; Department of Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK.
  • Rogelj B; Department of Biotechnology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
  • Houart C; MRC Centre for Developmental Neurobiology, London SE1 1UL, UK.
  • Shaw CE; Department of Clinical Neuroscience, King's College London, Institute of Psychiatry, London SE5 8AF, UK. Electronic address: christopher.shaw@kcl.ac.uk.
Cell Rep ; 5(5): 1178-86, 2013 Dec 12.
Article in En | MEDLINE | ID: mdl-24290757
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Proteins / RNA-Binding Proteins / Apoptosis / Microsatellite Repeats / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Cell Rep Year: 2013 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Proteins / RNA-Binding Proteins / Apoptosis / Microsatellite Repeats / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Cell Rep Year: 2013 Document type: Article Country of publication: Estados Unidos