Estrogen or raloxifene during postmenopausal weight loss: adiposity and cardiometabolic outcomes.
Obesity (Silver Spring)
; 22(4): 1024-31, 2014 Apr.
Article
in En
| MEDLINE
| ID: mdl-24311443
ABSTRACT
OBJECTIVE:
Estrogen-based hormone therapy (HT) attenuates abdominal fat gain after menopause, but whether HT improves abdominal fat loss during weight loss is unknown. It was hypothesized that HT or a selective estrogen receptor modulator (raloxifene) would augment reductions in abdominal visceral fat during weight loss when compared to placebo, potentially increasing improvements in glucose tolerance and lipid profile.METHODS:
Healthy postmenopausal women (n = 119; age 50-70 yr) underwent a 6-month weight-loss (primarily exercise) intervention with randomization to raloxifene (60 mg/d), HT (conjugated estrogens, 0.625 mg/d), or placebo. Outcomes were change in total and abdominal (visceral and subcutaneous) fat mass, lipid profile, and fasting and post-challenge glucose and insulin.RESULTS:
Neither HT nor raloxifene augmented loss of total or abdominal fat mass during exercise-induced weight loss when compared with placebo. Weight loss-induced improvements in risk factors were similar among the three groups, except for a greater reduction in fasted glucose in the HT group (difference in change [95%CI] from placebo; -0.40 [-0.76, -0.05]) and greater reductions in LDL (-0.36 [-0.63, -0.09]) and increases in HDL (0.15 [0.07, 0.24]) in both treatment groups.CONCLUSIONS:
Postmenopausal HT and raloxifene did not increase abdominal fat loss during weight loss, but did improve some cardiometabolic outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Estrogen Replacement Therapy
/
Raloxifene Hydrochloride
/
Selective Estrogen Receptor Modulators
/
Estrogens
/
Adiposity
/
Obesity
Type of study:
Clinical_trials
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Obesity (Silver Spring)
Journal subject:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Year:
2014
Document type:
Article
Affiliation country:
Estados Unidos