High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome.
Cardiovasc Diabetol
; 13: 9, 2014 Jan 09.
Article
in En
| MEDLINE
| ID: mdl-24400991
ABSTRACT
BACKGROUND:
The complement system is part of the immune system in acute coronary syndrome (ACS). Adiponectin has anti-atherogenic and anti-inflammatory properties. Adiponectin and C1q form a protein complex in blood, and serum C1q binding adiponectin (C1q-APN) can be measured. We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls.METHODS:
The study subjects were 138 Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays. Patients were divided into three groups according to the clinical condition ACS (n = 78), SAP (n = 41) or normal coronary (NC, n = 19) groups.RESULTS:
Serum C1q levels were significantly higher in the ACS group (54.9±1.2 µg/mL) than in the NC group (48.0±2.5 µg/mL). Although serum Total-APN levels were significantly lower in the SAP and ACS groups, compared with the NC group (7.0±0.5, 7.2±0.3, 10.6±2.0 µg/mL, respectively), serum C1q-APN levels were significantly higher in the ACS group than in the NC and SAP groups (112.1±4.1, 66.3±4.4, 65.7±2.9 units/mL, respectively).CONCLUSIONS:
Patients with ACS had higher serum C1q-APN levels. TRIAL REGISTRATION UMIN000002997.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adiponectin
/
Acute Coronary Syndrome
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cardiovasc Diabetol
Journal subject:
ANGIOLOGIA
/
CARDIOLOGIA
/
ENDOCRINOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Japón