Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation.
Theriogenology
; 81(5): 683-8, 2014 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-24411494
ABSTRACT
The ATP-binding cassette subfamily B member 1 (ABCB1) is an efflux transporter that excretes xenobiotics and waste matter. High expression of ABCB1 induced by forskolin (FSK) and rifampicin (RIF) in the bovine blastocysts reportedly improves the cellular quality. In the present study, interferon-α, similar to FSK and RIF, was highly potent in inducing the expression of ABCB1 in the bovine blastocysts but did not exhibit an additive effect with FSK and RIF. Bovine blastocysts stimulated by the combined treatment with FSK, RIF, and interferon-α to express high levels of ABCB1 displayed better freezing resistance as indicated by higher cell numbers in post thawing cultures. On transfer to recipients, such embryos established pregnancies with significantly higher frequencies in repeat breeder cows rather than normal ones.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Embryo Implantation
/
Cattle
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Theriogenology
Year:
2014
Document type:
Article