Clinical update on cancer: molecular oncology of head and neck cancer.
Cell Death Dis
; 5: e1018, 2014 Jan 23.
Article
in En
| MEDLINE
| ID: mdl-24457962
ABSTRACT
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are biologically aggressive in nature. These cancers remain difficult to treat and treatment can cause severe, long-term side effects. For patients who are not cured by surgery and/or (chemo)radiotherapy, there are few effective treatment options. Targeted therapies and predictive biomarkers are urgently needed in order to improve the management and minimise the treatment toxicity, and to allow selection of patients who are likely to benefit from both nonselective and targeted therapies. This clinical update aims to provide an insight into the current understanding of the molecular pathogenesis of the disease, and explores the novel therapies under development and in clinical trials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Molecular Targeted Therapy
/
Head and Neck Neoplasms
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Death Dis
Year:
2014
Document type:
Article
Affiliation country:
Reino Unido