Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies.

Chau, Nuy; Elliot, David J; Lewis, Benjamin C; Burns, Kushari; Johnston, Martin R; Mackenzie, Peter I; Miners, John O

Chau, Nuy; Elliot, David J; Lewis, Benjamin C; Burns, Kushari; Johnston, Martin R; Mackenzie, Peter I; Miners, John O.

Affiliation

Chau N; Department of Clinical Pharmacology, School of Medicine, Flinders University, Adelaide, Australia (N.C., D.J.E., B.C.L., K.B., P.I.M., J.O.M.); and School of Chemical and Physical Sciences, Flinders University, Adelaide, Australia (M.R.J.).

J Pharmacol Exp Ther ; 349(1): 126-37, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24459244

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Glucuronosyltransferase / Glucuronides / Molecular Docking Simulation / Glucosides / Morphine Limits: Humans Language: En Journal: J Pharmacol Exp Ther Year: 2014 Document type: Article Country of publication: Estados Unidos

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