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The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
Dowty, Martin E; Lin, Jinyan; Ryder, Tim F; Wang, Weiwei; Walker, Gregory S; Vaz, Alfin; Chan, Gary L; Krishnaswami, Sriram; Prakash, Chandra.
Affiliation
  • Dowty ME; Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Andover, Massachusetts (M.E.D.); Pfizer Inc., Groton, Connecticut (J.L., T.F.R., W.W., G.S.W., A.V., C.P.); and Departments of Specialty Care Clinical Affairs (G.L.C.) and Clinical Pharmacology (S.K.), Pfizer Inc., Groton, Connecticut.
Drug Metab Dispos ; 42(4): 759-73, 2014 Apr.
Article in En | MEDLINE | ID: mdl-24464803
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyrimidines / Pyrroles / Aryl Hydrocarbon Hydroxylases / Protein Kinase Inhibitors / Cytochrome P-450 CYP3A / Janus Kinases / Liver Limits: Female / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2014 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyrimidines / Pyrroles / Aryl Hydrocarbon Hydroxylases / Protein Kinase Inhibitors / Cytochrome P-450 CYP3A / Janus Kinases / Liver Limits: Female / Humans / Male Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2014 Document type: Article Country of publication: Estados Unidos