Safety, tolerability, pharmacokinetics, and effects on human experimental pain of the selective ionotropic glutamate receptor 5 (iGluR5) antagonist LY545694 in healthy volunteers.

Petersen, Karin L; Iyengar, Smriti; Chappell, Amy S; Lobo, Evelyn D; Reda, Haatem; Prucka, William R; Verfaille, Steven J

Petersen, Karin L; Iyengar, Smriti; Chappell, Amy S; Lobo, Evelyn D; Reda, Haatem; Prucka, William R; Verfaille, Steven J.

Affiliation

Petersen KL; California Pacific Medical Center Research Institute, San Francisco, CA, USA Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Pain ; 155(5): 929-936, 2014 May.

Article in En | MEDLINE | ID: mdl-24486883

Subject(s)
Key words

Analgesic; Antihyperalgesic; Brief thermal stimulation model; Efficacy; Human experimental pain model; Hyperalgesia; Ionotropic glutamate receptor 5 receptor antagonist

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Tetrazoles / Prodrugs / Excitatory Amino Acid Antagonists / Isoquinolines Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: Pain Year: 2014 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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