Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

Gonzalez, Ana Z; Eksterowicz, John; Bartberger, Michael D; Beck, Hilary P; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Fox, Brian M; Fu, Jiasheng; Huang, Xin; Houze, Jonathan B; Jin, Lixia; Li, Yihong; Li, Zhihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M; McGee, Lawrence R; McIntosh, Joel; McMinn, Dustin L; Oliner, Jonathan D; Osgood, Tao; Rew, Yosup; Saiki, Anne Y; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H; Medina, Julio C; Sun, Daqing

Gonzalez, Ana Z; Eksterowicz, John; Bartberger, Michael D; Beck, Hilary P; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Fox, Brian M; Fu, Jiasheng; Huang, Xin; Houze, Jonathan B; Jin, Lixia; Li, Yihong; Li, Zhihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M; McGee, Lawrence R; McIntosh, Joel; McMinn, Dustin L; Oliner, Jonathan D; Osgood, Tao; Rew, Yosup; Saiki, Anne Y; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H; Medina, Julio C; Sun, Daqing.

Affiliation

Gonzalez AZ; Departments of Therapeutic Discovery, Pharmaceutics, and §Pharmacokinetics and Drug Metabolism, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.

J Med Chem ; 57(6): 2472-88, 2014 Mar 27.

Article in En | MEDLINE | ID: mdl-24548297

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Morpholines / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins c-mdm2 / Acetates / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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