Cell Differentiation/immunology; Histocompatibility Antigens Class I/immunology; Killer Cells, Natural/immunology; Receptors, KIR/immunology; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters/deficiency; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/immunology; Adult; CD56 Antigen/immunology; CD56 Antigen/metabolism; CD57 Antigens/immunology; CD57 Antigens/metabolism; CD8 Antigens/immunology; CD8 Antigens/metabolism; Cell Differentiation/genetics; Female; Flow Cytometry; Genotype; HLA-A Antigens/genetics; HLA-A Antigens/immunology; HLA-A Antigens/metabolism; HLA-B Antigens/genetics; HLA-B Antigens/immunology; HLA-B Antigens/metabolism; HLA-C Antigens/genetics; HLA-C Antigens/immunology; HLA-C Antigens/metabolism; Histocompatibility Antigens Class I/genetics; Histocompatibility Antigens Class I/metabolism; Humans; Interferon-gamma/immunology; Interferon-gamma/metabolism; Killer Cells, Natural/metabolism; Lysosomal-Associated Membrane Protein 1/immunology; Lysosomal-Associated Membrane Protein 1/metabolism; Male; Middle Aged; Mutation; NK Cell Lectin-Like Receptor Subfamily C/immunology; NK Cell Lectin-Like Receptor Subfamily C/metabolism; Receptors, KIR/genetics; Receptors, KIR/metabolism