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Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.
Choi, Bryan D; Gedeon, Patrick C; Herndon, James E; Archer, Gary E; Reap, Elizabeth A; Sanchez-Perez, Luis; Mitchell, Duane A; Bigner, Darell D; Sampson, John H.
Affiliation
  • Choi BD; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710 ; Department of Pathology, Duke University Medical Center, Durham, NC 27710.
  • Gedeon PC; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710 ; Department of Biomedical Engineering, Duke University, Durham, NC 27708.
  • Herndon JE; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710.
  • Archer GE; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710.
  • Reap EA; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710.
  • Sanchez-Perez L; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710.
  • Mitchell DA; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710 ; Department of Pathology, Duke University Medical Center, Durham, NC 27710 ; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center,
  • Bigner DD; Department of Pathology, Duke University Medical Center, Durham, NC 27710 ; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, NC 27710.
  • Sampson JH; Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710 ; Department of Pathology, Duke University Medical Center, Durham, NC 27710 ; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center,
Cancer Immunol Res ; 1(3): 163, 2013 Sep.
Article in En | MEDLINE | ID: mdl-24570975
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Antibodies, Bispecific / Glioblastoma / Cytotoxicity, Immunologic / Granzymes / Perforin Limits: Humans Language: En Journal: Cancer Immunol Res Year: 2013 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Antibodies, Bispecific / Glioblastoma / Cytotoxicity, Immunologic / Granzymes / Perforin Limits: Humans Language: En Journal: Cancer Immunol Res Year: 2013 Document type: Article Country of publication: Estados Unidos