Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez, Ana Z; Li, Zhihong; Beck, Hilary P; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Eksterowicz, John; Fox, Brian M; Fu, Jiasheng; Huang, Xin; Houze, Jonathan; Jin, Lixia; Li, Yihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M; McGee, Lawrence R; McIntosh, Joel; Oliner, Jonathan D; Osgood, Tao; Rew, Yosup; Saiki, Anne Y; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H; Sun, Daqing; Medina, Julio C

Gonzalez, Ana Z; Li, Zhihong; Beck, Hilary P; Canon, Jude; Chen, Ada; Chow, David; Duquette, Jason; Eksterowicz, John; Fox, Brian M; Fu, Jiasheng; Huang, Xin; Houze, Jonathan; Jin, Lixia; Li, Yihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M; McGee, Lawrence R; McIntosh, Joel; Oliner, Jonathan D; Osgood, Tao; Rew, Yosup; Saiki, Anne Y; Shaffer, Paul; Wortman, Sarah; Yakowec, Peter; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H; Sun, Daqing; Medina, Julio C.

Affiliation

Gonzalez AZ; Departments of Therapeutic Discovery, Pharmaceutics, and §Pharmacokinetics and Drug Metabolism, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States.

J Med Chem ; 57(7): 2963-88, 2014 Apr 10.

Article in En | MEDLINE | ID: mdl-24601644

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidones / Carboxylic Acids / Tumor Suppressor Protein p53 / Myocytes, Smooth Muscle / Cell Proliferation / Proto-Oncogene Proteins c-mdm2 / Protein Interaction Domains and Motifs / Acetates / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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