Liver injury possibly related to drug interaction after liver transplant: a case report.
J Clin Pharm Ther
; 39(4): 439-41, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-24661191
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Drug-induced hepatotoxicity is potentially lethal. Liver transplant patients receive a large number of medications and adverse drug reactions, and drug-drug interactions must be closely monitored. CASESUMMARY:
We report a case of a 29-year-old liver transplant patient who suffered liver injury most likely induced by drug interaction between capecitabine and warfarin. Vitamin K1 caused skin rash possibly because of the distribution and metabolism characteristic of the drug in this patient. WHAT IS NEW ANDCONCLUSION:
Close monitoring and prompt discontinuation of the drugs with high volume of distribution and metabolized through the liver are necessary to avoid drug-drug interaction in liver transplant patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Warfarin
/
Liver Transplantation
/
Deoxycytidine
/
Chemical and Drug Induced Liver Injury
/
Fluorouracil
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
J Clin Pharm Ther
Journal subject:
FARMACIA
/
TERAPEUTICA
Year:
2014
Document type:
Article
Affiliation country:
China