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The role of surface functionality in nanoparticle exocytosis.
Kim, Chang Soo; Le, Ngoc D B; Xing, Yuqing; Yan, Bo; Tonga, Gulen Yesilbag; Kim, Chaekyu; Vachet, Richard W; Rotello, Vincent M.
Affiliation
  • Kim CS; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Le NDB; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Xing Y; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Yan B; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Tonga GY; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Kim C; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Vachet RW; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
  • Rotello VM; Department of Chemistry, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (USA).
Adv Healthc Mater ; 3(8): 1200-1202, 2014 Aug.
Article in En | MEDLINE | ID: mdl-24665047
ABSTRACT
Getting out is just as important for nano-therapeutics as getting in. Exocytosis rates determine residency time in the cell, an important determinant for therapeutic efficacy and also for eventual clearance from the cell. In this study, it is shown that exocytosis efficiency is determined by surface functionality, providing a strategy for optimizing nanocarriers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Nanoparticles Limits: Humans Language: En Journal: Adv Healthc Mater Year: 2014 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Nanoparticles Limits: Humans Language: En Journal: Adv Healthc Mater Year: 2014 Document type: Article