External validation of a prognostic model predicting overall survival in metastatic castrate-resistant prostate cancer patients treated with abiraterone.
Eur Urol
; 66(1): 8-11, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-24685433
ABSTRACT
A prognostic model was derived from the population of the COU-AA-301 phase 3 trial for metastatic castrate-resistant prostate cancer patients treated with abiraterone after docetaxel, and it stratifies patients into three risk groups based on clinical parameters. We validated this model in an independent cohort of patients treated with abiraterone after docetaxel outside a clinical trial (group A; n=94) and explored its utility in patients treated with abiraterone in the prechemotherapy setting (group B; n=64). For group A, median overall survival (mOS) was significantly different across the three prognostic groups (good n=39, mOS 21.8 mo; intermediate n=44, mOS 10.6 mo; poor n=7, mOS 6.8 mo; p<0.001; area under the curve [AUC] 0.71). Analysis of group B confirmed the ability of the model to prognosticate for survival in the prechemotherapy setting:
(good n=44, mOS 45.6 mo; intermediate or poor n=20, mOS 34.5 mo; p=0.042; AUC 0.61). These results serve to validate the prognostic model in an independent population treated with abiraterone after docetaxel and support clinical implementation of the score. Calibration of the model was poorer in patients receiving abiraterone prechemotherapy. Prospective evaluation of this model in clinical trials is needed.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antineoplastic Combined Chemotherapy Protocols
/
Prostatic Neoplasms, Castration-Resistant
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Urol
Year:
2014
Document type:
Article
Affiliation country:
Reino Unido