Early radiation-induced changes evaluated by intravoxel incoherent motion in the major salivary glands.
J Magn Reson Imaging
; 41(4): 974-82, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-24700435
ABSTRACT
PURPOSE:
To investigate the potential of intravoxel incoherent motion (IVIM) MRI for early evaluation of irradiated major salivary glands. MATERIALS ANDMETHODS:
Thirty-four patients with head-neck cancer were included in a prospective study. All patients underwent three serial IVIM-MRI before, half-way through, and at the end of radiotherapy (RT). Apparent diffusion coefficient (ADC), ADClow derived in the low b-value range, perfusion fraction f, and pure diffusion coefficient D were estimated. Pretreatment values and early changes of diffusion parameters were correlated with parotid mean dose (Dmean ) and volume reduction after RT.RESULTS:
Changes in diffusion parameters over time were all significant (P < 0.001 for ADC, ADClow , and D, P = 0.003 for f). Variations of ADC, ADClow , and f were not correlated with Dmean (P = 0.089, P = 0.252 and P = 0.884, respectively), whereas a significant relationship was found between changes in D and Dmean (r = 0.197 with CI95% = 0.004-0.375, P = 0.046). Pretreatment f and Dmean were the best independent predictors for the percentage shrinkage (P = 0.0003 and 0.0597 respectively; R(2) = 0.391).CONCLUSION:
Early changes of irradiated major salivary glands can be noninvasively evaluated by IVIM-MRI. Perfusion-related coefficients in conjunction with dosimetric information increase our capability to predict the change in parotid volume and hence, if further validated, guide treatment strategy in RT.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salivary Gland Diseases
/
Magnetic Resonance Imaging
/
Image Interpretation, Computer-Assisted
/
Radiotherapy, Conformal
/
Head and Neck Neoplasms
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Magn Reson Imaging
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2015
Document type:
Article
Affiliation country:
Italia