A novel technique for the measurement of CBF and CBV with robot-arm-mounted flat panel CT in a large-animal model.
AJNR Am J Neuroradiol
; 35(9): 1740-5, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-24831590
ABSTRACT
BACKGROUND AND PURPOSE:
Endovascular therapy is an emerging treatment option in patients with acute ischemic stroke and especially in cases presenting late after symptom onset. Information about remaining viable tissue as measured with perfusion imaging is crucial for proper patient selection. The aim of this study was to investigate whether perfusion imaging with C-arm CT in the angiography suite is feasible and provides measurements comparable with ones made by CTP. MATERIALS ANDMETHODS:
The MCA was occluded surgically in 6 sheep. Perfusion studies were performed before surgery, immediately after, and at 3 hours after MCA occlusion by using a robotic flat panel detector C-arm angiographic system. For comparison, conventional CTP was performed at the same time points. Two different protocols with the C-arm CT were tested. Images were analyzed by 2 readers with regard to the presence and size of perfusion abnormalities.RESULTS:
With C-arm CT, perfusion abnormalities were detected with a high sensitivity and specificity when vessel occlusion was confirmed by criterion standard DSA. No difference was found between lesions sizes measured with the 2 C-arm CT protocols and CTP. Growth of the CBV lesions with time was captured with C-arm CT and CTP.CONCLUSIONS:
In this small study, it was feasible to qualitatively measure CBV and CBF by using a flat panel detector angiographic system.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Robotics
/
Cerebral Angiography
/
Cerebrovascular Circulation
/
Stroke
/
Perfusion Imaging
Type of study:
Guideline
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
AJNR Am J Neuroradiol
Year:
2014
Document type:
Article