Prospective neurobiological effects of the aerial and root extracts and some pure compounds of randomly selected Scorzonera species.
Pharm Biol
; 52(7): 873-82, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-24920233
ABSTRACT
CONTEXT Scorzonera L. species (Asteraceae) are edible and as medicinal plants are used for various purposed in folk medicine. OBJECTIVE:
The methanol extracts of the aerial parts and roots from 27 Scorzonera taxa were investigated for their possible neurobiological effects. MATERIALS ANDMETHODS:
Inhibitory potential of the Scorzonera species was tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYRO) at 100 µg mL(-1) using ELISA microtiter assay. Antioxidant activity of the extracts was tested with radical scavenging activity, metal-chelation capacity, ferric- (FRAP), and phosphomolibdenum-reducing antioxidant power (PRAP) assays. Chlorogenic acid, hyperoside, rutin, and scorzotomentosin-4-O-ß-glucoside were also screened in the same manner. Total phenol and flavonoid quantification in the extracts were determined spectrophotometrically.RESULTS:
The aerial parts of Scorzonera pisidica (40.25 ± 0.74%) and chlorogenic acid (46.97 ± 0.82%) displayed the highest TYRO inhibition, while the remaining samples showed only trivial inhibition against cholinesterases (2.08 ± 1.35%-25.32 ± 1.37%). The same extract of S. pisidica was revealed to be the most potent in scavenging of all three radicals and FRAP assay. DISCUSSION ANDCONCLUSION:
Out of 27 taxa, S. pisidica, in particular, may deserve further investigation for its neuroprotective potential.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Cholinesterase Inhibitors
/
Plant Roots
/
Neuroprotective Agents
/
Scorzonera
/
Plant Components, Aerial
/
Isocoumarins
/
Glucosides
Type of study:
Clinical_trials
Language:
En
Journal:
Pharm Biol
Year:
2014
Document type:
Article
Affiliation country:
Turquía