From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
Chem Commun (Camb)
; 50(62): 8593-6, 2014 Aug 11.
Article
in En
| MEDLINE
| ID: mdl-24956071
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Bcl-X Protein
/
Cycloaddition Reaction
/
Myeloid Cell Leukemia Sequence 1 Protein
Type of study:
Prognostic_studies
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2014
Document type:
Article
Affiliation country:
Francia
Country of publication:
Reino Unido