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Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance.
Meakin, Paul J; Chowdhry, Sudhir; Sharma, Ritu S; Ashford, Fiona B; Walsh, Shaun V; McCrimmon, Rory J; Dinkova-Kostova, Albena T; Dillon, John F; Hayes, John D; Ashford, Michael L J.
Affiliation
  • Meakin PJ; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Chowdhry S; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Sharma RS; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Ashford FB; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Walsh SV; Department of Pathology, Ninewells Hospital and Medical School, Tayside NHS Trust, Dundee, Scotland, United Kingdom.
  • McCrimmon RJ; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Dinkova-Kostova AT; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Dillon JF; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
  • Hayes JD; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom m.l.j.ashford@dundee.ac.uk j.d.hayes@dundee.ac.uk.
  • Ashford ML; Medical Research Institute, Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom m.l.j.ashford@dundee.ac.uk j.d.hayes@dundee.ac.uk.
Mol Cell Biol ; 34(17): 3305-20, 2014 Sep.
Article in En | MEDLINE | ID: mdl-24958099

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Non-alcoholic Fatty Liver Disease / Liver Cirrhosis, Experimental Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Mol Cell Biol Year: 2014 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Non-alcoholic Fatty Liver Disease / Liver Cirrhosis, Experimental Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Mol Cell Biol Year: 2014 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos