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HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck.
Carlson, Jonathan M; Schaefer, Malinda; Monaco, Daniela C; Batorsky, Rebecca; Claiborne, Daniel T; Prince, Jessica; Deymier, Martin J; Ende, Zachary S; Klatt, Nichole R; DeZiel, Charles E; Lin, Tien-Ho; Peng, Jian; Seese, Aaron M; Shapiro, Roger; Frater, John; Ndung'u, Thumbi; Tang, Jianming; Goepfert, Paul; Gilmour, Jill; Price, Matt A; Kilembe, William; Heckerman, David; Goulder, Philip J R; Allen, Todd M; Allen, Susan; Hunter, Eric.
Affiliation
  • Carlson JM; Microsoft Research, Redmond, WA 98052, USA. carlson@microsoft.com ehunte4@emory.edu.
  • Schaefer M; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Monaco DC; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Batorsky R; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02114, USA.
  • Claiborne DT; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Prince J; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Deymier MJ; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Ende ZS; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Klatt NR; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • DeZiel CE; Microsoft Research, Redmond, WA 98052, USA.
  • Lin TH; Microsoft Research, Redmond, WA 98052, USA.
  • Peng J; Microsoft Research, Redmond, WA 98052, USA.
  • Seese AM; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02114, USA.
  • Shapiro R; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Frater J; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX1 7BN, UK. National Institute of Health Research, Oxford Biomedical Research Centre, Oxford OX3 7LE, UK. Oxford Martin School, University of Oxford, Oxford OX1 3BD, UK.
  • Ndung'u T; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02114, USA. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4013, South Africa.
  • Tang J; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Goepfert P; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Gilmour J; International AIDS Vaccine Initiative, London SW10 9NH, UK. Imperial College of Science Technology and Medicine, London SW10 9NH, UK.
  • Price MA; International AIDS Vaccine Initiative, San Francisco, CA 94105, USA. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA.
  • Kilembe W; Rwanda-Zambia HIV Research Group: Zambia-Emory HIV Research Project, Lusaka, Zambia.
  • Heckerman D; Microsoft Research, Los Angeles, CA 98117, USA.
  • Goulder PJ; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban 4013, South Africa. Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
  • Allen TM; Rwanda-Zambia HIV Research Group: Zambia-Emory HIV Research Project, Lusaka, Zambia. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
  • Allen S; International AIDS Vaccine Initiative, San Francisco, CA 94105, USA. Microsoft Research, Los Angeles, CA 98117, USA. Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
  • Hunter E; Emory Vaccine Center at Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA. Rwanda-Zambia HIV Research Group: Zambia-Emory HIV Research Project, Lusaka, Zambia. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA. carlson@microsoft
Science ; 345(6193): 1254031, 2014 Jul 11.
Article in En | MEDLINE | ID: mdl-25013080
ABSTRACT
Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / HIV Infections / HIV-1 / Heterosexuality Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Science Year: 2014 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / HIV Infections / HIV-1 / Heterosexuality Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Science Year: 2014 Document type: Article