A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

Jahagirdar, Ravi; Zhang, Haiyan; Azhar, Salman; Tobin, Jennifer; Attwell, Sarah; Yu, Raymond; Wu, Jin; McLure, Kevin G; Hansen, Henrik C; Wagner, Gregory S; Young, Peter R; Srivastava, Rai Ajit K; Wong, Norman C W; Johansson, Jan

Jahagirdar, Ravi; Zhang, Haiyan; Azhar, Salman; Tobin, Jennifer; Attwell, Sarah; Yu, Raymond; Wu, Jin; McLure, Kevin G; Hansen, Henrik C; Wagner, Gregory S; Young, Peter R; Srivastava, Rai Ajit K; Wong, Norman C W; Johansson, Jan.

Affiliation

Jahagirdar R; Resverlogix Corp., Calgary, Canada. Electronic address: ravi@resverlogix.com.
Zhang H; VA Palo Alto Health Care System, Palo Alto, USA.
Azhar S; VA Palo Alto Health Care System, Palo Alto, USA.
Tobin J; Resverlogix Corp., Calgary, Canada.
Attwell S; Resverlogix Corp., Calgary, Canada.
Yu R; Resverlogix Corp., Calgary, Canada.
Wu J; Resverlogix Corp., Calgary, Canada.
McLure KG; Resverlogix Corp., Calgary, Canada.
Hansen HC; Resverlogix Corp., Calgary, Canada.
Wagner GS; Resverlogix Corp., Calgary, Canada.
Young PR; Resverlogix Corp., Calgary, Canada.
Srivastava RA; Integrated Pharma Solutions, Philadelphia, USA.
Wong NC; Resverlogix Corp., Calgary, Canada.
Johansson J; Resverlogix Corp., Calgary, Canada.

Atherosclerosis ; 236(1): 91-100, 2014 Sep.

Article in En | MEDLINE | ID: mdl-25016363

Subject(s)
Key words

Atherosclerosis; BET inhibitor; Inflammation; Preß-HDL; RVX-208; apoA-I-inducer; apoE deficient

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aortic Diseases / Quinazolines / Atherosclerosis / Betaine-Homocysteine S-Methyltransferase / Hyperlipidemias Type of study: Etiology_studies Language: En Journal: Atherosclerosis Year: 2014 Document type: Article Country of publication: Irlanda

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