Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin.

Huang, Yijun; Reis, Edimara S; Knerr, Patrick J; van der Donk, Wilfred A; Ricklin, Daniel; Lambris, John D

Huang, Yijun; Reis, Edimara S; Knerr, Patrick J; van der Donk, Wilfred A; Ricklin, Daniel; Lambris, John D.

Affiliation

Huang Y; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 401 Stellar-Chance Laboratories, Philadelphia, PA 19104 (USA).

ChemMedChem ; 9(10): 2223-6, 2014 Oct.

Article in En | MEDLINE | ID: mdl-25056114

Subject(s)
Key words

albumin binding; complement inhibitor; compstatin; conjugation; peptide drugs

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Albumins / Complement Inactivating Agents Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2014 Document type: Article Country of publication: Alemania

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