Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability.

Ali, Ahmed Y; Kim, Ji-Young; Pelletier, Jean-François; Vanderhyden, Barbara C; Bachvarov, Dimcho R; Tsang, Benjamin K

Ali, Ahmed Y; Kim, Ji-Young; Pelletier, Jean-François; Vanderhyden, Barbara C; Bachvarov, Dimcho R; Tsang, Benjamin K.

Affiliation

Ali AY; Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Kim JY; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Pelletier JF; Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Vanderhyden BC; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Bachvarov DR; Département de Médecine Moleculaire, Faculté de Médecine, Université Laval, Québec City, Québec, Canada.
Tsang BK; Centre de Recherche du CHU de Québec, L'Hôtel-Dieu de Québec, Québec City, Québec, Canada.

Mol Carcinog ; 54(11): 1301-14, 2015 Nov.

Article in En | MEDLINE | ID: mdl-25154814

Subject(s)
Key words

Akt; PPM1D; apoptosis; cisplatin chemoresistance; ovarian cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma / Cisplatin / Phosphoprotein Phosphatases / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-akt / Genital Neoplasms, Female Limits: Animals / Female / Humans / Middle aged Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Canadá Country of publication: Estados Unidos

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