Acne pathogenesis: history of concepts.
Dermatology
; 229(1): 1-46, 2014.
Article
in En
| MEDLINE
| ID: mdl-25228295
ABSTRACT
From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propionibacterium acnes
/
Sebum
/
Gram-Positive Bacterial Infections
/
Skin Diseases, Bacterial
/
Dermatitis, Seborrheic
/
Acne Vulgaris
/
Inflammation
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Dermatology
Journal subject:
DERMATOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Francia