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DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.
DeLoughery, Zachary; Luczak, Michal W; Ortega-Atienza, Sara; Zhitkovich, Anatoly.
Affiliation
  • DeLoughery Z; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912.
  • Luczak MW; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912.
  • Ortega-Atienza S; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912.
  • Zhitkovich A; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912 anatoly_zhitkovich@brown.edu.
Toxicol Sci ; 143(1): 54-63, 2015 Jan.
Article in En | MEDLINE | ID: mdl-25288669
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Cell Nucleus / Chromates / Chromium / Potassium Compounds / Euchromatin / DNA Breaks, Double-Stranded Limits: Animals / Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Histones / Cell Nucleus / Chromates / Chromium / Potassium Compounds / Euchromatin / DNA Breaks, Double-Stranded Limits: Animals / Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Document type: Article Country of publication: Estados Unidos