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Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia.
Hahn, Alana M; Myers, Jason D; McFarland, Eliza K; Lee, Sanghee; Jerde, Travis J.
Affiliation
  • Hahn AM; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana (A.M.H., J.D.M., T.J.J.); Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin (E.K.M., S.L.); and Melvin and Bren Simon Cancer Center, Indiana Basic Urological Rese
  • Myers JD; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana (A.M.H., J.D.M., T.J.J.); Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin (E.K.M., S.L.); and Melvin and Bren Simon Cancer Center, Indiana Basic Urological Rese
  • McFarland EK; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana (A.M.H., J.D.M., T.J.J.); Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin (E.K.M., S.L.); and Melvin and Bren Simon Cancer Center, Indiana Basic Urological Rese
  • Lee S; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana (A.M.H., J.D.M., T.J.J.); Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin (E.K.M., S.L.); and Melvin and Bren Simon Cancer Center, Indiana Basic Urological Rese
  • Jerde TJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana (A.M.H., J.D.M., T.J.J.); Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, Wisconsin (E.K.M., S.L.); and Melvin and Bren Simon Cancer Center, Indiana Basic Urological Rese
J Pharmacol Exp Ther ; 351(3): 605-15, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25292180
ABSTRACT
Prostatic inflammation is of considerable importance to urologic research because of its association with benign prostatic hyperplasia and prostate cancer. However, the mechanisms by which inflammation leads to proliferation and growth remain obscure. Here, we show that insulin-like growth factors (IGFs), previously known as critical developmental growth factors during prostate organogenesis, are induced by inflammation as part of the proliferative recovery to inflammation. Using genetic models and in vivo IGF receptor blockade, we demonstrate that the hyperplastic response to inflammation depends on interleukin-1-driven IGF signaling. We show that human prostatic hyperplasia is associated with IGF pathway activation specifically localized to foci of inflammation. This demonstrates that mechanisms of inflammation-induced epithelial proliferation and hyperplasia involve the induction of developmental growth factors, further establishing a link between inflammatory and developmental signals and providing a mechanistic basis for the management of proliferative diseases by IGF pathway modulation.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Somatomedins / Interleukin-1 Type of study: Prognostic_studies Limits: Aged / Animals / Humans / Male / Middle aged Language: En Journal: J Pharmacol Exp Ther Year: 2014 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Somatomedins / Interleukin-1 Type of study: Prognostic_studies Limits: Aged / Animals / Humans / Male / Middle aged Language: En Journal: J Pharmacol Exp Ther Year: 2014 Document type: Article