L-fucose from vitamin C with only acetonide protection.
Org Lett
; 16(21): 5663-5, 2014 Nov 07.
Article
in En
| MEDLINE
| ID: mdl-25310515
ABSTRACT
Addition of human milk oligosaccharides (HMO) to baby foods may protect infants from disease. As many simple HMOs are fucosylated this is likely to increase the demand for L-fucose as a synthetic building block. Any chemical synthesis must be cheap to compete with a biotechnological process. Acetonide is the only protecting group we have used in this new synthesis of L-fucose from vitamin C in 27% overall yield (purification by recrystallization; no chromatography required in the entire sequence).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligosaccharides
/
Ascorbic Acid
/
Fucose
/
Milk, Human
Limits:
Humans
/
Infant
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2014
Document type:
Article
Affiliation country:
Reino Unido